Over the years the Medical Portfolio strategies have evolved to meet the ever-changing challenges in U.S. and global health care. Despite significant advances in medicine and technology, global health crises are on the rise, necessitating increased and targeted investments in this space. PCLB grants substantially to MSF-Doctors Without Borders, a well-known organization that has for years been at the forefront in fighting the world’s most dangerous diseases in locations where few others would accept the risk. A global impact in health care is possible with PCLB’s support to organizations such as MSF-Doctors Without Borders.